| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium-Dependent Lysophosphatidylcholine Symporter 1 (464-543) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MFSD2A |
| Gene ID: |
84879 |
| Uniprot ID: |
NLS1_HUMAN |
| Immunogen Region: |
464-543 |
| Immunogen: |
Recombinant fusion protein containing a sequence within amino acids 464-543 of human MFSD2A (NP_001129965.1). |
| Immunogen Sequence: |
DFAGYQTRGCSQPERVKFTL NMLVTMAPIVLILLGLLLFK MYPIDEERRRQNKKALQALR DEASSSGCSETDSTELASIL |
| Tissue Specificity | In placenta, associated with trophoblast cells. |
| Function | Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion. |
| Protein Name | Sodium-Dependent Lysophosphatidylcholine Symporter 1Nls1Sodium-Dependent Lpc Symporter 1Major Facilitator Superfamily Domain-Containing Protein 2aHsmfsd2aMfsd2a |
| Database Links | Reactome: R-HSA-1483191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmic Punctae That May Represent Vesicles Shuttling Between The Endoplasmic Reticulum And The Plasma Membrane |
| Alternative Antibody Names | Anti-Sodium-Dependent Lysophosphatidylcholine Symporter 1 antibodyAnti-Nls1 antibodyAnti-Sodium-Dependent Lpc Symporter 1 antibodyAnti-Major Facilitator Superfamily Domain-Containing Protein 2a antibodyAnti-Hsmfsd2a antibodyAnti-Mfsd2a antibodyAnti-MFSD2A antibodyAnti-MFSD2 antibodyAnti-NLS1 antibodyAnti-HMFN0656 antibodyAnti-PP9177 antibodyAnti-UNQ300 antibodyAnti-PRO341 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
