| Tissue Specificity | In placenta, associated with trophoblast cells. |
| Function | Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion. |
| Protein Name | Sodium-Dependent Lysophosphatidylcholine Symporter 1Nls1Sodium-Dependent Lpc Symporter 1Major Facilitator Superfamily Domain-Containing Protein 2aHsmfsd2aMfsd2a |
| Database Links | Reactome: R-HSA-1483191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmic Punctae That May Represent Vesicles Shuttling Between The Endoplasmic Reticulum And The Plasma Membrane |
| Alternative Antibody Names | Anti-Sodium-Dependent Lysophosphatidylcholine Symporter 1 antibodyAnti-Nls1 antibodyAnti-Sodium-Dependent Lpc Symporter 1 antibodyAnti-Major Facilitator Superfamily Domain-Containing Protein 2a antibodyAnti-Hsmfsd2a antibodyAnti-Mfsd2a antibodyAnti-MFSD2A antibodyAnti-MFSD2 antibodyAnti-NLS1 antibodyAnti-HMFN0656 antibodyAnti-PP9177 antibodyAnti-UNQ300 antibodyAnti-PRO341 antibody |
Information sourced from Uniprot.org
