| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Mfsd2a |
| Gene ID: | 76574 |
| Uniprot ID: | NLS1_MOUSE |
| Immunogen Region: | 170-245 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-245 of mouse Mfsd2a (NP_083938.2). |
| Immunogen Sequence: | SALTMFISTEQSERDSATAY RMTVEVLGTVIGTAIQGQIV GQAKAPCLQDQNGSVVVSEV ANRTQSTASLKDTQNA |
| Tissue Specificity | Widely expressed. Exhibits an oscillatory pattern of expression in brown adipose tissue and liver consistent with a circadian rhythm. Enriched in brain micro-vessels, where it is specifically present in endothelium constituting the blood-brain barrier (at protein level). |
| Post Translational Modifications | N-glycosylated. |
| Function | Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Not required for central nervous system vascular morphogenesis. |
| Protein Name | Sodium-Dependent Lysophosphatidylcholine Symporter 1 Nls1 Sodium-Dependent Lpc Symporter 1 Major Facilitator Superfamily Domain-Containing Protein 2a Mfsd2a |
| Database Links | Reactome: R-MMU-1483191 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Sodium-Dependent Lysophosphatidylcholine Symporter 1 antibody Anti-Nls1 antibody Anti-Sodium-Dependent Lpc Symporter 1 antibody Anti-Major Facilitator Superfamily Domain-Containing Protein 2a antibody Anti-Mfsd2a antibody Anti-Mfsd2a antibody Anti-Mfsd2 antibody Anti-Nls1 antibody |
Information sourced from Uniprot.org