| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
METRNL |
| Gene ID: |
284207 |
| Uniprot ID: |
METRL_HUMAN |
| Immunogen Region: |
179-311 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 179-311 of mouse METRNL. (NP_001004431.1). |
| Immunogen Sequence: |
SDLHELSAPCRPCSDTEVLL AVCTSDFAVRGSIQQVTHEP ERQDSAIHLRVSRLYRQKSR VFEPVPEGDGHWQGRVRTLL ECGVRPGHGDFLFTGHMHFG EARLGCAPRFKDFQRMYRDA QERGLNPCEVGTD |
| Tissue Specificity | Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. |
| Function | Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. |
| Protein Name | Meteorin-Like ProteinSubfatin |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Meteorin-Like Protein antibodyAnti-Subfatin antibodyAnti-METRNL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
