| Post Translational Modifications | Degraded by the proteasome. |
| Function | Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. |
| Protein Name | Mesoderm Posterior Protein 2Class C Basic Helix-Loop-Helix Protein 6Bhlhc6 |
| Database Links | Reactome: R-HSA-9824272 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mesoderm Posterior Protein 2 antibodyAnti-Class C Basic Helix-Loop-Helix Protein 6 antibodyAnti-Bhlhc6 antibodyAnti-MESP2 antibodyAnti-BHLHC6 antibodyAnti-SCDO2 antibody |
Information sourced from Uniprot.org
