| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | MESP2 |
| Gene ID: | 145873 |
| Uniprot ID: | MESP2_HUMAN |
| Immunogen Region: | 218-397 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 218-397 of human MESP2 (NP_001035047.1). |
| Immunogen Sequence: | ASWGSPSACPGAQAAPERLG RGVHDTDPWATPPYCPKIQS PPYSSQGTTSDASLWTPPQG CPWTQSSPEPRNPPVPWTAA PATLELAAVYQGLSVSPEPC LSLGAPSLLPHPSCQRLQPQ TPGRCWSHSAEVVPNSEDQG PGAAFQLSEASPPQSSGLRF SGCPELWQEDLEGARLGIFY |
| Post Translational Modifications | Degraded by the proteasome. |
| Function | Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. |
| Protein Name | Mesoderm Posterior Protein 2 Class C Basic Helix-Loop-Helix Protein 6 Bhlhc6 |
| Database Links | Reactome: R-HSA-9824272 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mesoderm Posterior Protein 2 antibody Anti-Class C Basic Helix-Loop-Helix Protein 6 antibody Anti-Bhlhc6 antibody Anti-MESP2 antibody Anti-BHLHC6 antibody Anti-SCDO2 antibody |
Information sourced from Uniprot.org