Anti-MEPCE antibody (STJA0007061)

SKU:
STJA0007061

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-7SK snRNA methylphosphate capping enzyme is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MEPCE
Gene ID: 56257
Uniprot ID: MEPCE_HUMAN
Specificity: This antibody detects endogenous levels of MEPCE at Human, Mouse
Immunogen: Synthesized peptide derived from human MEPCE
Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex.interaction with LARP7 within the 7SK RNP complex occluding its catalytic center.
Protein Name 7sk Snrna Methylphosphate Capping Enzyme
Mepce
Bicoid-Interacting Protein 3 Homolog
Bin3 Homolog
Cellular Localisation Nucleus
Alternative Antibody Names Anti-7sk Snrna Methylphosphate Capping Enzyme antibody
Anti-Mepce antibody
Anti-Bicoid-Interacting Protein 3 Homolog antibody
Anti-Bin3 Homolog antibody
Anti-MEPCE antibody
Anti-BCDIN3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance