| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-7SK snRNA methylphosphate capping enzyme is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MEPCE |
| Gene ID: | 56257 |
| Uniprot ID: | MEPCE_HUMAN |
| Specificity: | This antibody detects endogenous levels of MEPCE at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human MEPCE |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex.interaction with LARP7 within the 7SK RNP complex occluding its catalytic center. Also required for stability of U6 snRNAs. |
| Protein Name | 7sk Snrna Methylphosphate Capping Enzyme Mepce Bicoid-Interacting Protein 3 Homolog Bin3 Homolog |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-7sk Snrna Methylphosphate Capping Enzyme antibody Anti-Mepce antibody Anti-Bicoid-Interacting Protein 3 Homolog antibody Anti-Bin3 Homolog antibody Anti-MEPCE antibody Anti-BCDIN3 antibody |
Information sourced from Uniprot.org