| Tissue Specificity | Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex.interaction with LARP7 within the 7SK RNP complex occluding its catalytic center. Also required for stability of U6 snRNAs. |
| Protein Name | 7sk Snrna Methylphosphate Capping EnzymeMepceBicoid-Interacting Protein 3 HomologBin3 Homolog |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-7sk Snrna Methylphosphate Capping Enzyme antibodyAnti-Mepce antibodyAnti-Bicoid-Interacting Protein 3 Homolog antibodyAnti-Bin3 Homolog antibodyAnti-MEPCE antibodyAnti-BCDIN3 antibody |
Information sourced from Uniprot.org
