Anti-MEN1 antibody (266-615) (STJ117485)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MEN1 (266-615) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MEN1 |
| Gene ID | 4221 |
| Uniprot ID | MEN1_HUMAN |
| Immunogen Region | 266-615 |
| Immunogen Sequence | QKLLWLLYDLGHLERYPMAL GNLADLEELEPTPGRPDPLT LYHKGIASAKTYYRDEHIYP YMYLAGYHCRNRNVREALQA WADTATVIQDYNYCREDEEI YKEFFEVANDVIPNLLKEAA SLLEAGEERPGEQSQGTQSQ GSALQDPECFAHLLRFYDGI CKWEEGSPTPVLHVGWATFL VQSLGRFEGQVRQKVRIVSR EAEAAEAEEPWGEEAREGRR RGPRRESKPEEPPPPKKPA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 266-615 of human Menin (NP_000235.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. |
| Protein Name | Menin |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2173796Reactome: R-HSA-3769402Reactome: R-HSA-381426Reactome: R-HSA-5626467Reactome: R-HSA-8957275Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusConcentrated In Nuclear Body-Like StructuresRelocates To The Nuclear Matrix Upon Gamma Irradiation |
| Alternative Antibody Names | Anti-Menin antibodyAnti-MEN1 antibodyAnti-SCG2 antibody |
Information sourced from Uniprot.org