| Short Description : | Rabbit polyclonal MEMO1 (1-297) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MEMO1 |
| Gene ID: | 51072 |
| Uniprot ID: | MEMO1_HUMAN |
| Immunogen Region: | 1-297 |
| Immunogen Sequence: | MSNRVVCREASHAGSWYTAS GPQLNAQLEGWLSQVQSTKR PARAIIAPHAGYTYCGSCAA HAYKQVDPSITRRIFILGPS HHVPLSRCALSSVDIYRTPL YDLRIDQKIYGELWKTGMFE RMSLQTDEDEHSIEMHLPYT AKAMESHKDEFTIIPVLVGA LSESKEQEFGKLFSKYLADP SNLFVVSSDFCHWGQRFRYS YYDESQGEIYRSIEHLDKMG MSIIEQLDPVSFSNYLKKY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human MEMO1 (NP_057039.1). |
| Function | May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. |
| Protein Name | Protein Memo1C21orf19-Like ProteinHepatitis C Virus Ns5a-Transactivated Protein 7Hcv Ns5a-Transactivated Protein 7Mediator Of Erbb2-Driven Cell Motility 1Mediator Of Cell Motility 1Memo-1 |
| Database Links | Reactome: R-HSA-6785631 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Protein Memo1 antibodyAnti-C21orf19-Like Protein antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 7 antibodyAnti-Hcv Ns5a-Transactivated Protein 7 antibodyAnti-Mediator Of Erbb2-Driven Cell Motility 1 antibodyAnti-Mediator Of Cell Motility 1 antibodyAnti-Memo-1 antibodyAnti-MEMO1 antibodyAnti-C2orf4 antibodyAnti-MEMO antibodyAnti-NS5ATP7 antibodyAnti-CGI-27 antibody |
Information sourced from Uniprot.org
