| Post Translational Modifications | Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable). |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity.phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. |
| Protein Name | Maternal Embryonic Leucine Zipper KinaseHmelkProtein Kinase Eg3Peg3 KinaseProtein Kinase Pk38Hpk38Tyrosine-Protein Kinase Melk |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Maternal Embryonic Leucine Zipper Kinase antibodyAnti-Hmelk antibodyAnti-Protein Kinase Eg3 antibodyAnti-Peg3 Kinase antibodyAnti-Protein Kinase Pk38 antibodyAnti-Hpk38 antibodyAnti-Tyrosine-Protein Kinase Melk antibodyAnti-MELK antibodyAnti-KIAA0175 antibody |
Information sourced from Uniprot.org
