Host: | Mouse |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-MAP2K1 is suitable for use in Western Blot research applications. |
Clonality: | Monoclonal |
Clone ID: | 6F10-D7-G6 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | MAP2K2 |
Gene ID: | 5605 |
Uniprot ID: | MP2K2_HUMAN |
Specificity: | This antibody detects endogenous levels of MEK1/2 and does not cross-react with related proteins. |
Immunogen: | Recombinant human MEK1 protein. |
Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. |
Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 Map Kinase Kinase 2 Mapkk 2 Erk Activator Kinase 2 Mapk/Erk Kinase 2 Mek 2 |
Database Links | Reactome: R-HSA-112411 Reactome: R-HSA-170968 Reactome: R-HSA-445144 Reactome: R-HSA-5210891 Reactome: R-HSA-5673000 Reactome: R-HSA-5674135 Reactome: R-HSA-5674499 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9652169 Reactome: R-HSA-9656223 |
Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein Membrane Localization Is Probably Regulated By Its Interaction With Ksr1 |
Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 antibody Anti-Map Kinase Kinase 2 antibody Anti-Mapkk 2 antibody Anti-Erk Activator Kinase 2 antibody Anti-Mapk/Erk Kinase 2 antibody Anti-Mek 2 antibody Anti-MAP2K2 antibody Anti-MEK2 antibody Anti-MKK2 antibody Anti-PRKMK2 antibody |
Information sourced from Uniprot.org