| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus. Phosphorylation increases its interaction with PSIP1. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 1Activator-Recruited Cofactor 205 Kda ComponentArc205Mediator Complex Subunit 1Peroxisome Proliferator-Activated Receptor-Binding ProteinPbpPpar-Binding ProteinThyroid Hormone Receptor-Associated Protein Complex 220 Kda ComponentTrap220Thyroid Receptor-Interacting Protein 2Tr-Interacting Protein 2Trip-2Vitamin D Receptor-Interacting Protein Complex Component Drip205P53 Regulatory Protein Rb18a |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9833110 |
| Cellular Localisation | NucleusA Subset Of The Protein May Enter The Nucleolus Subsequent To Phosphorylation By Mapk1 Or Mapk3 |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 1 antibodyAnti-Activator-Recruited Cofactor 205 Kda Component antibodyAnti-Arc205 antibodyAnti-Mediator Complex Subunit 1 antibodyAnti-Peroxisome Proliferator-Activated Receptor-Binding Protein antibodyAnti-Pbp antibodyAnti-Ppar-Binding Protein antibodyAnti-Thyroid Hormone Receptor-Associated Protein Complex 220 Kda Component antibodyAnti-Trap220 antibodyAnti-Thyroid Receptor-Interacting Protein 2 antibodyAnti-Tr-Interacting Protein 2 antibodyAnti-Trip-2 antibodyAnti-Vitamin D Receptor-Interacting Protein Complex Component Drip205 antibodyAnti-P53 Regulatory Protein Rb18a antibodyAnti-MED1 antibodyAnti-ARC205 antibodyAnti-CRSP1 antibodyAnti-CRSP200 antibodyAnti-DRIP205 antibodyAnti-DRIP230 antibodyAnti-PBP antibodyAnti-PPARBP antibodyAnti-PPARGBP antibodyAnti-RB18A antibodyAnti-TRAP220 antibodyAnti-TRIP2 antibody |
Information sourced from Uniprot.org
