Anti-MDFIC antibody (100-180 aa) (STJ191000)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 100-180
General Information
| Short Description | Rabbit polyclonal anti-MyoD family inhibitor domain-containing protein (100-180 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MDFIC |
| Gene ID | 29969 |
| Uniprot ID | MDFIC_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 100-180 |
| Immunogen Region | 100-180 aa |
| Specificity | MDFIC Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Palmitoylated. |
| Function | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation. Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Involved in the development of lymphatic vessel valves. Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix. Regulates the activity of mechanosensitive Piezo channel. (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. |
| Protein Name | Myod Family Inhibitor Domain-Containing ProteinI-Mfa Domain-Containing ProteinHic |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusNucleolusAlso Shows A Granular Distribution In The CytoplasmIsoform 2: CytoplasmSecreted |
| Alternative Antibody Names | Anti-Myod Family Inhibitor Domain-Containing Protein antibodyAnti-I-Mfa Domain-Containing Protein antibodyAnti-Hic antibodyAnti-MDFIC antibody |
Information sourced from Uniprot.org