| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCRS1 |
| Gene ID: |
10445 |
| Uniprot ID: |
MCRS1_HUMAN |
| Immunogen Region: |
203-462 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 203-462 of human MCRS1 (NP_006328.2). |
| Immunogen Sequence: |
IQSKALFSKAEEQLLSKVGS TSQPTLETFQDLLHRHPDAF YLARTAKALQAHWQLMKQYY LLEDQTVQPLPKGDQVLNFS DAEDLIDDSKLKDMRDEVLE HELMVADRRQKREIRQLEQE LHKWQVLVDSITGMSSPDFD NQTLAVLRGRMVRYLMRSRE ITLGRATKDNQIDVDLSLEG PAWKISRKQGVIKLKNNGDF FIANEGRRPIYIDGRPVLCG SKWRLSNNSVVEIASLRFV |
| Tissue Specificity | Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes. |
| Post Translational Modifications | Ubiquitinated by UBR5 when not assembled in the INO80 complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when MCRS1 is part of the INO80 complex. |
| Function | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U). |
| Protein Name | Microspherule Protein 158 Kda Microspherule ProteinCell Cycle-Regulated Factor P78Ino80 Complex Subunit JMcrs2 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689603Reactome: R-HSA-5696394Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusNucleolusCytoplasmIn Microspherules In The Nucleolus |
| Alternative Antibody Names | Anti-Microspherule Protein 1 antibodyAnti-58 Kda Microspherule Protein antibodyAnti-Cell Cycle-Regulated Factor P78 antibodyAnti-Ino80 Complex Subunit J antibodyAnti-Mcrs2 antibodyAnti-MCRS1 antibodyAnti-INO80Q antibodyAnti-MSP58 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
