Anti-MCOLN3 antibody (STJA0009351)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MCOLN3
Gene ID:	55283
Uniprot ID:	MCLN3_HUMAN
Specificity:	This antibody detects endogenous levels of Mucolipin 3 at Human, Mouse
Immunogen:	Synthesized peptide derived from human Mucolipin 3

Function	Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3.
Protein Name	Mucolipin-3 Transient Receptor Potential Channel Mucolipin 3 Trpml3
Database Links	Reactome: R-HSA-3295583
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Early Endosome Membrane Late Endosome Membrane Lysosome Membrane Cytoplasmic Vesicle Autophagosome Membrane Recycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic Pathway Under Normal Conditions Only A Very Minor Proportion Is Present At The Cell Membrane In The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links
Alternative Antibody Names	Anti-Mucolipin-3 antibody Anti-Transient Receptor Potential Channel Mucolipin 3 antibody Anti-Trpml3 antibody Anti-MCOLN3 antibody

Information sourced from Uniprot.org

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