| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mucolipin-3 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCOLN3 |
| Gene ID: |
55283 |
| Uniprot ID: |
MCLN3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Mucolipin 3 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human Mucolipin 3 |
| Function | Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3. |
| Protein Name | Mucolipin-3Transient Receptor Potential Channel Mucolipin 3Trpml3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneLate Endosome MembraneLysosome MembraneCytoplasmic VesicleAutophagosome MembraneRecycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic PathwayUnder Normal ConditionsOnly A Very Minor Proportion Is Present At The Cell MembraneIn The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links |
| Alternative Antibody Names | Anti-Mucolipin-3 antibodyAnti-Transient Receptor Potential Channel Mucolipin 3 antibodyAnti-Trpml3 antibodyAnti-MCOLN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
