| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCM10 |
| Gene ID: | 55388 |
| Uniprot ID: | MCM10_HUMAN |
| Immunogen Region: | 616-875 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1). |
| Immunogen Sequence: | RLEGAPATMTPKLGRGVLEG DDVLFYDESPPPRPKLSALA EAKKLAAITKLRAKGQVLTK TNPNSIKKKQKDPQDILEVK ERVEKNTMFSSQAEDELEPA RKKRREQLAYLESEEFQKIL KAKSKHTGILKEAEAEMQER YFEPLVKKEQMEEKMRNIRE VKCRVVTCKTCAYTHFKLLE TCVSEQHEYHWHDGVKRFFK CPCGNRSISLDRLPNKHCSN CGLYKWERDGMLKEKTGPK |
| Function | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability.acts as a direct target of transcriptional repression by ZBTB38. |
| Protein Name | Protein Mcm10 HomologHsmcm10 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusColocalizes With Orc2 In Nuclei FociAssociated With Chromatin In S PhaseFrom Early To Mid-S Phase Located In Discrete Nuclear FociIn Early S PhaseSeveral Hundred Foci Appeared Throughout The NucleusIn Mid-S PhaseThe Foci Appeared At The Nuclear Periphery And Nucleolar RegionsIn The Late S And G Phases Localized To Nucleoli |
| Alternative Antibody Names | Anti-Protein Mcm10 Homolog antibodyAnti-Hsmcm10 antibodyAnti-MCM10 antibodyAnti-PRO2249 antibody |
Information sourced from Uniprot.org