| Host: | Mouse |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Induced myeloid leukemia cell differentiation protein Mcl-1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 8C6/8C6D4B1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide. |
| Purification: | Affinity purification |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCL1 |
| Gene ID: | 4170 |
| Uniprot ID: | MCL1_HUMAN |
| Specificity: | Mcl-1 Monoclonal Antibody detects endogenous levels of Mcl-1 protein. |
| Immunogen: | Purified recombinant fragment of human MCL-1 expressed in E. Coli. |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Protein Name | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1Bcl-2-Like Protein 3Bcl2-L-3Bcl-2-Related Protein Eat/Mcl1Mcl1/Eat |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9725370 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmMitochondrionNucleusNucleoplasmCytoplasmicAssociated With Mitochondria |
| Alternative Antibody Names | Anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 antibodyAnti-Bcl-2-Like Protein 3 antibodyAnti-Bcl2-L-3 antibodyAnti-Bcl-2-Related Protein Eat/Mcl1 antibodyAnti-Mcl1/Eat antibodyAnti-MCL1 antibodyAnti-BCL2L3 antibody |
Information sourced from Uniprot.org