| Short Description : | Rabbit monoclonal anti-MBD3 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ICC/IF |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R06-6D4 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | MBD3 |
| Gene ID: | 53615 |
| Uniprot ID: | MBD3_HUMAN |
| Immunogen: | A synthesized peptide derived from human MBD3 |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to methylated DNA by itself. Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 3Methyl-Cpg-Binding Protein Mbd3 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeNuclearIn Discrete FociDetected On ChromatinAt Promoter Regions Of Active Genes |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 3 antibodyAnti-Methyl-Cpg-Binding Protein Mbd3 antibodyAnti-MBD3 antibody |
Information sourced from Uniprot.org
