| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MBD2-Isoform 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-2.5µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MBD2 |
| Gene ID: |
8932 |
| Uniprot ID: |
MBD2_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_003918.1 |
| Specificity: |
This antibody is expected to resognize isoform 1 (NP_003918.1) only. |
| Immunogen Sequence: |
RNDPLNQNKGKPDLN |
| Function | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 2DemethylaseDmtaseMethyl-Cpg-Binding Protein Mbd2 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-73728 |
| Cellular Localisation | NucleusChromosomeNuclearIn Discrete FociDetected At Replication Foci In Late S PhaseLocalizes To Methylated ChromatinLocalizes To Sites Of Dna Damage In A Manner Partially Dependent On Zmynd8 |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 2 antibodyAnti-Demethylase antibodyAnti-Dmtase antibodyAnti-Methyl-Cpg-Binding Protein Mbd2 antibodyAnti-MBD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
