Anti-MATK antibody (352-466) (STJ28734)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MATK (352-466) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MATK |
| Gene ID | 4145 |
| Uniprot ID | MATK_HUMAN |
| Immunogen Region | 352-466 |
| Immunogen Sequence | PEALKHGKFTSKSDVWSFGV LLWEVFSYGRAPYPKMSLKE VSEAVEKGYRMEPPEGCPGP VHVLMSSCWEAEPARRPPFR KLAEKLARELRSAGAPASVS GQDADGSTSPRSQEP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1). |
Additional Info
| Tissue Specificity | Expressed in various myeloid cell lines, detected in brain and lung. |
| Function | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. |
| Protein Name | Megakaryocyte-Associated Tyrosine-Protein KinaseCsk Homologous KinaseChkHematopoietic Consensus Tyrosine-Lacking KinaseProtein Kinase HylTyrosine-Protein Kinase Ctk |
| Database Links | Reactome: R-HSA-8863795 |
| Cellular Localisation | CytoplasmMembraneIn Platelets90% Of Matk Localizes To The Membrane FractionAnd Translocates To The Cytoskeleton Upon Thrombin Stimulation |
| Alternative Antibody Names | Anti-Megakaryocyte-Associated Tyrosine-Protein Kinase antibodyAnti-Csk Homologous Kinase antibodyAnti-Chk antibodyAnti-Hematopoietic Consensus Tyrosine-Lacking Kinase antibodyAnti-Protein Kinase Hyl antibodyAnti-Tyrosine-Protein Kinase Ctk antibodyAnti-MATK antibodyAnti-CTK antibodyAnti-HYL antibody |
Information sourced from Uniprot.org