Anti-Mast Cell Tryptase antibody [R03-6A5] (STJA0036060)

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STJA0036060
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Host: Rabbit
Applications: WB/IHC-P/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Mast Cell Tryptase for use in WB, IHC-P and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R03-6A5
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IP 1:50
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: TPSAB1
Gene ID: 7177
Uniprot ID: TRYB1_HUMAN
Immunogen: A synthesized peptide derived from human Mast Cell Tryptase
Tissue Specificity Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin.in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Protein Name Tryptase Alpha/Beta-1
Tryptase-1
Tryptase I
Tryptase Alpha-1
Database Links Reactome: R-HSA-1592389
Cellular Localisation Secreted
Released From The Secretory Granules Upon Mast Cell Activation
Alternative Antibody Names Anti-Tryptase Alpha/Beta-1 antibody
Anti-Tryptase-1 antibody
Anti-Tryptase I antibody
Anti-Tryptase Alpha-1 antibody
Anti-TPSAB1 antibody
Anti-TPS1 antibody
Anti-TPS2 antibody
Anti-TPSB1 antibody

Information sourced from Uniprot.org

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