| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAS1 |
| Gene ID: | 4142 |
| Uniprot ID: | MAS_HUMAN |
| Immunogen Region: | 246-325 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 246-325 of human MAS1 (NP_002368.1). |
| Immunogen Sequence: | LLYLLYYEYWSTFGNLHHIS LLFSTINSSANPFIYFFVGS SKKKRFKESLKVVLTRAFKD EMQPRRQKDNCNTVTVETVV |
| Function | Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. |
| Protein Name | Proto-Oncogene Mas |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Proto-Oncogene Mas antibodyAnti-MAS1 antibodyAnti-MAS antibody |
Information sourced from Uniprot.org