| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MARVELD2 |
| Gene ID: | 153562 |
| Uniprot ID: | MALD2_HUMAN |
| Immunogen Region: | 200-300 |
| Immunogen Sequence: | ELLLGAGVFACVTAYIHKDS EWYNLFGYSQPYGMGGVGGL GSMYGGYYYTGPKTPFVLVV AGLAWITTIIILVLGMSMYY RTILLDSNWWPLTEFGINVA L |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MARVELD2 (NP_001033692.2). |
| Post Translational Modifications | Ubiquitinated by ITCH.but this ubiquitination does not lead to proteasomal degradation. Polyubiquitinated at Lys-412 via 'Lys-63'-linked ubiquitin chains.deubiquitinated by USP53. Phosphorylated. |
| Function | Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti. |
| Protein Name | Marvel Domain-Containing Protein 2Tricellulin |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionTight JunctionLocated At Tricellular Contacts |
| Alternative Antibody Names | Anti-Marvel Domain-Containing Protein 2 antibodyAnti-Tricellulin antibodyAnti-MARVELD2 antibodyAnti-TRIC antibody |
Information sourced from Uniprot.org
