| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAPK6 (372-721) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAPK6 |
| Gene ID: |
5597 |
| Uniprot ID: |
MK06_HUMAN |
| Immunogen Region: |
372-721 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 372-721 of human MAPK6 (NP_002739.1). |
| Immunogen Sequence: |
NFDIDEVQLDPRALSDVTDE EEVQVDPRKYLDGDREKYLE DPAFDTNYSTEPCWQYSDHH ENKYCDLECSHTCNYKTRSS SYLDNLVWRESEVNHYYEPK LIIDLSNWKEQSKEKSDKKG KSKCERNGLVKAQIALEEAS QQLAGKEREKNQGFDFDSFI AGTIQLSSQHEPTDVVDKLN DLNSSVSQLELKSLISKSVS QEKQEKGMANLAQLEALYQS SWDSQFVSGGEDCFFINQF |
| Tissue Specificity | Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
| Post Translational Modifications | Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Ubiquitination at Met-1 leads to degradation by the proteasome pathway. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. |
| Protein Name | Mitogen-Activated Protein Kinase 6Map Kinase 6Mapk 6Extracellular Signal-Regulated Kinase 3Erk-3Map Kinase Isoform P97P97-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase 6 antibodyAnti-Map Kinase 6 antibodyAnti-Mapk 6 antibodyAnti-Extracellular Signal-Regulated Kinase 3 antibodyAnti-Erk-3 antibodyAnti-Map Kinase Isoform P97 antibodyAnti-P97-Mapk antibodyAnti-MAPK6 antibodyAnti-ERK3 antibodyAnti-PRKM6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
