| Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3Germinal Center Kinase-Related Protein KinaseGlkMapk/Erk Kinase Kinase Kinase 3Mek Kinase Kinase 3Mekkk 3 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 antibodyAnti-Germinal Center Kinase-Related Protein Kinase antibodyAnti-Glk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 3 antibodyAnti-Mek Kinase Kinase 3 antibodyAnti-Mekkk 3 antibodyAnti-MAP4K3 antibodyAnti-RAB8IPL1 antibody |
Information sourced from Uniprot.org
