| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAP4K3 |
| Gene ID: |
8491 |
| Uniprot ID: |
M4K3_HUMAN |
| Immunogen Region: |
755-894 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 755-894 of human MAP4K3 (NP_003609.2). |
| Immunogen Sequence: |
ETVNPNSTSSWFTESDTPQT NVTHVTQLERDTILVCLDCC IKIVNLQGRLKSSRKLSSEL TFDFQIESIVCLQDSVLAFW KHGMQGRSFRSNEVTQEISD STRIFRLLGSDRVVVLESRP TDNPTANSNLYILAGHENSY |
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3Germinal Center Kinase-Related Protein KinaseGlkMapk/Erk Kinase Kinase Kinase 3Mek Kinase Kinase 3Mekkk 3 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 antibodyAnti-Germinal Center Kinase-Related Protein Kinase antibodyAnti-Glk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 3 antibodyAnti-Mek Kinase Kinase 3 antibodyAnti-Mekkk 3 antibodyAnti-MAP4K3 antibodyAnti-RAB8IPL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
