| Short Description : | Rabbit polyclonal anti-Mitogen-activated protein kinase kinase kinase kinase 3 (10-59 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP4K3 |
| Gene ID: | 8491 |
| Uniprot ID: | M4K3_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MAP4K3 at the amino acid range 10-59 |
| Immunogen Region: | 10-59 aa |
| Specificity: | GLK Polyclonal Antibody detects endogenous levels of GLK protein. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3Germinal Center Kinase-Related Protein KinaseGlkMapk/Erk Kinase Kinase Kinase 3Mek Kinase Kinase 3Mekkk 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 antibodyAnti-Germinal Center Kinase-Related Protein Kinase antibodyAnti-Glk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 3 antibodyAnti-Mek Kinase Kinase 3 antibodyAnti-Mekkk 3 antibodyAnti-MAP4K3 antibodyAnti-RAB8IPL1 antibody |
Information sourced from Uniprot.org
