| Tissue Specificity | Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. |
| Post Translational Modifications | Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308. |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 9Mixed Lineage Kinase 1 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 9 antibodyAnti-Mixed Lineage Kinase 1 antibodyAnti-MAP3K9 antibodyAnti-MLK1 antibodyAnti-PRKE1 antibody |
Information sourced from Uniprot.org
