| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MAP3K7IP3 (59-69) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-3.75µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TAB3 |
| Gene ID: |
257397 |
| Uniprot ID: |
TAB3_HUMAN |
| Immunogen Region: |
59-69 |
| Accession Number: |
NP_690000.2 |
| Immunogen Sequence: |
HSPDDNRMNRN |
| Post Translational Modifications | Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination.leading to TAK1/MAP3K7 activation. Degraded in a lysosome-dependent manner following interactiuon with TRIM38. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. (Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. |
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Isoform 2: May be an oncogenic factor. |
| Protein Name | Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3Nf-Kappa-B-Activating Protein 1Tak1-Binding Protein 3Tab-3Tgf-Beta-Activated Kinase 1-Binding Protein 3 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5357956Reactome: R-HSA-5607764Reactome: R-HSA-9014325Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9645460Reactome: R-HSA-9705671Reactome: R-HSA-975163 |
| Alternative Antibody Names | Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 antibodyAnti-Nf-Kappa-B-Activating Protein 1 antibodyAnti-Tak1-Binding Protein 3 antibodyAnti-Tab-3 antibodyAnti-Tgf-Beta-Activated Kinase 1-Binding Protein 3 antibodyAnti-TAB3 antibodyAnti-MAP3K7IP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
