| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP3K3 |
| Gene ID: | 4215 |
| Uniprot ID: | M3K3_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEKK3 (Q99759). |
| Immunogen Sequence: | MDEQEALNSIMNDLVALQMN RRHRMPGYETMKNKDTGHSN RQSDVRIKFEHNGERRIIAF SRPVKYEDVEHKVTTVFGQP LDLHYMNNELSILLKNQDDL |
| Post Translational Modifications | Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. |
| Function | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 3Mapk/Erk Kinase Kinase 3Mek Kinase 3Mekk 3 |
| Database Links | Reactome: R-HSA-9020702 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 3 antibodyAnti-Mapk/Erk Kinase Kinase 3 antibodyAnti-Mek Kinase 3 antibodyAnti-Mekk 3 antibodyAnti-MAP3K3 antibodyAnti-MAPKKK3 antibodyAnti-MEKK3 antibody |
Information sourced from Uniprot.org