Anti-MAP3K14 antibody [SAA1891] (STJA0020319)

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STJA0020319
€426.88 - €1,809.38
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Mitogen-Activated Protein Kinase Kinase Kinase 14 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1891
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: MAP3K14
Gene ID: 9020
Uniprot ID: M3K14_HUMAN
Post Translational Modifications Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
Function Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 14
Nf-Kappa-Beta-Inducing Kinase
Hsnik
Serine/Threonine-Protein Kinase Nik
Database Links Reactome: R-HSA-389357
Reactome: R-HSA-5607761
Reactome: R-HSA-5668541
Reactome: R-HSA-5676590
Reactome: R-HSA-5676594
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 14 antibody
Anti-Nf-Kappa-Beta-Inducing Kinase antibody
Anti-Hsnik antibody
Anti-Serine/Threonine-Protein Kinase Nik antibody
Anti-MAP3K14 antibody
Anti-NIK antibody

Information sourced from Uniprot.org