| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAP3K14 (330-662) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAP3K14 |
| Gene ID: |
9020 |
| Uniprot ID: |
M3K14_HUMAN |
| Immunogen Region: |
330-662 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 330-662 of human MAP3K14 (NP_003945.2). |
| Immunogen Sequence: |
KFSVEEYLVHALQGSVSSGQ AHSLTSLAKTWAARGSRSRE PSPKTEDNEGVLLTEKLKPV DYEYREEVHWATHQLRLGRG SFGEVHRMEDKQTGFQCAVK KVRLEVFRAEELMACAGLTS PRIVPLYGAVREGPWVNIFM ELLEGGSLGQLVKEQGCLPE DRALYYLGQALEGLEYLHSR RILHGDVKADNVLLSSDGSH AALCDFGHAVCLQPDGLGKS LLTGDYIPGTETHMAPEVV |
| Tissue Specificity | Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. |
| Post Translational Modifications | Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it. |
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 14Nf-Kappa-Beta-Inducing KinaseHsnikSerine/Threonine-Protein Kinase Nik |
| Database Links | Reactome: R-HSA-389357Reactome: R-HSA-5607761Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5676594 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 14 antibodyAnti-Nf-Kappa-Beta-Inducing Kinase antibodyAnti-Hsnik antibodyAnti-Serine/Threonine-Protein Kinase Nik antibodyAnti-MAP3K14 antibodyAnti-NIK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
