• Western blot with Anti-MAP3K14 Antibody (STJ501669) of rat testis at 1:500 dilution in buffer.

Anti-MAP3K14 antibody (250-350) (STJ501669)

SKU:
STJ501669-100

£441.50
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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MAP3K14 (250-350) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.64-0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MAP3K14
Gene ID: 9020
Uniprot ID: M3K14_HUMAN
Immunogen Region: 250-350
Immunogen: Synthetic peptide taken within amino acid region 250-350 on human MAP3K14 protein.
Tissue Specificity Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
Post Translational Modifications Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
Function Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 14
Nf-Kappa-Beta-Inducing Kinase
Hsnik
Serine/Threonine-Protein Kinase Nik
Database Links Reactome: R-HSA-389357
Reactome: R-HSA-5607761
Reactome: R-HSA-5668541
Reactome: R-HSA-5676590
Reactome: R-HSA-5676594
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 14 antibody
Anti-Nf-Kappa-Beta-Inducing Kinase antibody
Anti-Hsnik antibody
Anti-Serine/Threonine-Protein Kinase Nik antibody
Anti-MAP3K14 antibody
Anti-NIK antibody

Information sourced from Uniprot.org

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