• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MLK3 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-MAP3K11 antibody (640-689) (STJ94151)

SKU:
STJ94151

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mitogen-activated protein kinase kinase kinase 11 (640-689) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP3K11
Gene ID: 4296
Uniprot ID: M3K11_HUMAN
Immunogen Region: 640-689
Specificity: MLK3 Polyclonal Antibody detects endogenous levels of MLK3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human MLK3. AA range:640-689
Tissue Specificity Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Post Translational Modifications Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 11
Mixed Lineage Kinase 3
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Database Links Reactome: R-HSA-5673000
Reactome: R-HSA-6802946
Reactome: R-HSA-6802955
Reactome: R-HSA-9013148
Reactome: R-HSA-9013408
Reactome: R-HSA-9013424
Reactome: R-HSA-9649948
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Location Is Cell Cycle Dependent
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 11 antibody
Anti-Mixed Lineage Kinase 3 antibody
Anti-Src-Homology 3 Domain-Containing Proline-Rich Kinase antibody
Anti-MAP3K11 antibody
Anti-MLK3 antibody
Anti-PTK1 antibody
Anti-SPRK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance