Anti-MAP2K5 antibody (STJ197347)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant Protein of MEK-5
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity mitogen-activated protein kinase kinase 5 for use in WB, IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000IHC 1:200-500IF 1:50-200 |
| Formulation | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP2K5 |
| Gene ID | 5607 |
| Uniprot ID | MP2K5_HUMAN |
| Immunogen | Recombinant Protein of MEK-5 |
| Specificity | The antibody detects endogenous MEK-5 protein. |
Additional Info
| Post Translational Modifications | Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 5Map Kinase Kinase 5Mapkk 5Mapk/Erk Kinase 5Mek 5 |
| Database Links | Reactome: R-HSA-198765 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 antibodyAnti-Map Kinase Kinase 5 antibodyAnti-Mapkk 5 antibodyAnti-Mapk/Erk Kinase 5 antibodyAnti-Mek 5 antibodyAnti-MAP2K5 antibodyAnti-MEK5 antibodyAnti-MKK5 antibodyAnti-PRKMK5 antibody |
Information sourced from Uniprot.org