| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Post Translational Modifications | Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3Map Kinase Kinase 3Mapkk 3Mapk/Erk Kinase 3Mek 3Stress-Activated Protein Kinase Kinase 2Sapk Kinase 2Sapkk-2Sapkk2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-450302Reactome: R-HSA-5210891 P46734-3 |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 antibodyAnti-Map Kinase Kinase 3 antibodyAnti-Mapkk 3 antibodyAnti-Mapk/Erk Kinase 3 antibodyAnti-Mek 3 antibodyAnti-Stress-Activated Protein Kinase Kinase 2 antibodyAnti-Sapk Kinase 2 antibodyAnti-Sapkk-2 antibodyAnti-Sapkk2 antibodyAnti-MAP2K3 antibodyAnti-MEK3 antibodyAnti-MKK3 antibodyAnti-PRKMK3 antibodyAnti-SKK2 antibody |
Information sourced from Uniprot.org
