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Anti-MAP2K2 antibody [7F5] (STJ98237)

Immunofluorescence analysis of Hela cells using MEK-2 monoclonal antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric analysis of Hela cells using MEK-2 monoclonal antibody (green) and negative control (purple).
Western blot analysis using MEK-2 monoclonal antibody against PC-12 (1) , Jurkat (2) , HeLa (3) and NIH/3T3 (4) cell lysate.

Anti-MAP2K2 antibody [7F5] (STJ98237)

SKU:

STJ98237

£139.00 - £336.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	WB/IF/FC/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Dual specificity mitogen-activated protein kinase kinase 2 is suitable for use in Western Blot, Immunofluorescence, Flow Cytometry and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	7F5
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF 1:200-1:1000 FC 1:200-1:400 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MAP2K2
Gene ID:	5605
Uniprot ID:	MP2K2_HUMAN
Specificity:	MEK-2 Monoclonal Antibody detects endogenous levels of MEK-2 protein.
Immunogen:	Purified recombinant fragment of human MEK-2 expressed in E. Coli.

Function	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
Protein Name	Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 Map Kinase Kinase 2 Mapkk 2 Erk Activator Kinase 2 Mapk/Erk Kinase 2 Mek 2
Database Links	Reactome: R-HSA-112411 Reactome: R-HSA-170968 Reactome: R-HSA-445144 Reactome: R-HSA-5210891 Reactome: R-HSA-5673000 Reactome: R-HSA-5674135 Reactome: R-HSA-5674499 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9652169 Reactome: R-HSA-9656223
Cellular Localisation	Cytoplasm Membrane Peripheral Membrane Protein Membrane Localization Is Probably Regulated By Its Interaction With Ksr1
Alternative Antibody Names	Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 antibody Anti-Map Kinase Kinase 2 antibody Anti-Mapkk 2 antibody Anti-Erk Activator Kinase 2 antibody Anti-Mapk/Erk Kinase 2 antibody Anti-Mek 2 antibody Anti-MAP2K2 antibody Anti-MEK2 antibody Anti-MKK2 antibody Anti-PRKMK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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