Anti-MANF antibody (80-120) {FITC} (STJ501656)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 80-120 on human Mesencephalic astrocyte-derived neurotrophic factor.
General Information
| Short Description | Rabbit polyclonal antibody anti-MANF (80-120) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:50, 000IP: 1:200IHC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MANF |
| Gene ID | 7873 |
| Uniprot ID | MANF_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 80-120 on human Mesencephalic astrocyte-derived neurotrophic factor. |
| Immunogen Region | 80-120 |
Additional Info
| Post Translational Modifications | May contain sialic acid residues. |
| Function | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. |
| Protein Name | Mesencephalic Astrocyte-Derived Neurotrophic FactorArginine-Rich ProteinProtein Armet |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedEndoplasmic Reticulum LumenSarcoplasmic Reticulum LumenRetained In The Endoplasmic Reticulum (Er)And Sarcoplasmic Reticulum (Sr) Under Normal ConditionsUp-Regulated And Secreted By The Er/Sr In Response To Er Stress And Hypoxia |
| Alternative Antibody Names | Anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor antibodyAnti-Arginine-Rich Protein antibodyAnti-Protein Armet antibodyAnti-MANF antibodyAnti-ARMET antibodyAnti-ARP antibody |
Information sourced from Uniprot.org