| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAN1C1 |
| Gene ID: | 57134 |
| Uniprot ID: | MA1C1_HUMAN |
| Immunogen Region: | 44-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-240 of human MAN1C1 (NP_065112.1). |
| Immunogen Sequence: | PHSSRLKRLFLAPRTQQPGL EVVAEIAGHAPAREQEPPPN PAPAAPAPGEDDPSSWASPR RRKGGLRRTRPTGPREEATA ARGNSIPASRPGDEGVPFRF DFNAFRSRLRHPVLGTRADE SQEPQSQVRAQREKIKEMMQ FAWQSYKRYAMGKNELRPLT KDGYEGNMFGGLSGATVIDS LDTLYLMELKEEFQEAK |
| Tissue Specificity | Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta. |
| Function | Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. |
| Protein Name | Mannosyl-Oligosaccharide 1 -2-Alpha-Mannosidase IcHmicMannosidase Alpha Class 1c Member 1Processing Alpha-1 -2-Mannosidase IcAlpha-1 -2-Mannosidase Ic |
| Database Links | Reactome: R-HSA-6811438Reactome: R-HSA-964827 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Mannosyl-Oligosaccharide 1 -2-Alpha-Mannosidase Ic antibodyAnti-Hmic antibodyAnti-Mannosidase Alpha Class 1c Member 1 antibodyAnti-Processing Alpha-1 -2-Mannosidase Ic antibodyAnti-Alpha-1 -2-Mannosidase Ic antibodyAnti-MAN1C1 antibodyAnti-MAN1A3 antibodyAnti-MAN1C antibody |
Information sourced from Uniprot.org