| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase (100-180 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAN1B1 |
| Gene ID: | 11253 |
| Uniprot ID: | MA1B1_HUMAN |
| Immunogen Region: | 100-180 aa |
| Specificity: | MAN1B1 Polyclonal Antibody detects endogenous levels of MAN1B1 protein. |
| Immunogen: | Synthesized peptide derived from MAN1B1 at the amino acid range 100-180 |
| Function | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). |
| Protein Name | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1 -2-Alpha-MannosidaseEr Alpha-1 -2-MannosidaseEr Mannosidase 1Erman1Man9glcnac2-Specific-Processing Alpha-MannosidaseMannosidase Alpha Class 1b Member 1 |
| Database Links | Reactome: R-HSA-4793950Reactome: R-HSA-901032Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Endoplasmic Reticulum Mannosyl-Oligosaccharide 1 -2-Alpha-Mannosidase antibodyAnti-Er Alpha-1 -2-Mannosidase antibodyAnti-Er Mannosidase 1 antibodyAnti-Erman1 antibodyAnti-Man9glcnac2-Specific-Processing Alpha-Mannosidase antibodyAnti-Mannosidase Alpha Class 1b Member 1 antibodyAnti-MAN1B1 antibodyAnti-UNQ747 antibodyAnti-PRO1477 antibody |
Information sourced from Uniprot.org
