• Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Western blot analysis of lysates from HUVEC cells, using MALT1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HUVEC cells using MALT1 Polyclonal Antibody

Anti-MALT1 antibody (301-350 aa) (STJ93995)

SKU:
STJ93995

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (301-350 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MALT1
Gene ID: 10892
Uniprot ID: MALT1_HUMAN
Immunogen Region: 301-350 aa
Specificity: MALT1 Polyclonal Antibody detects endogenous levels of MALT1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MALT1 at the amino acid range 301-350
Function Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
Protein Name Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1
Malt Lymphoma-Associated Translocation
Paracaspase
Database Links Reactome: R-HSA-1169091
Reactome: R-HSA-202424
Reactome: R-HSA-2871837
Reactome: R-HSA-5607764
Reactome: R-HSA-5660668
Cellular Localisation Cytoplasm
Perinuclear Region
Nucleus
Shuttles Between The Nucleus And Cytoplasm
Found In Perinuclear Structures Together With Bcl10
Alternative Antibody Names Anti-Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 antibody
Anti-Malt Lymphoma-Associated Translocation antibody
Anti-Paracaspase antibody
Anti-MALT1 antibody
Anti-MLT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance