| Function | Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3Membrane-Associated Guanylate Kinase Inverted 3Magi-3 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell JunctionTight JunctionNucleusConcentrates In Specific Sites At The Plasma Membrane And In The NucleusIn Epithelial CellsIt Localizes At Tight Junctions |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3 antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 3 antibodyAnti-Magi-3 antibodyAnti-Magi3 antibodyAnti-Kiaa1634 antibody |
Information sourced from Uniprot.org
