| Tissue Specificity | Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is an inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. |
| Function | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. |
| Protein Name | Melanoma-Associated Antigen C2Cancer/Testis Antigen 10Ct10Hepatocellular Carcinoma-Associated Antigen 587Mage-C2 AntigenMage-E1 Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNuclear In Germ CellsCytoplasmic In Well-Differentiated Hepatocellular CarcinomaNuclear In Moderately- And Poorly-Differentiated Hepatocellular Carcinoma |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen C2 antibodyAnti-Cancer/Testis Antigen 10 antibodyAnti-Ct10 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 587 antibodyAnti-Mage-C2 Antigen antibodyAnti-Mage-E1 Antigen antibodyAnti-MAGEC2 antibodyAnti-HCA587 antibodyAnti-MAGEE1 antibody |
Information sourced from Uniprot.org
