| Short Description : | Rabbit polyclonal anti-Transcription factor MafA (204-254 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAFA |
| Gene ID: | 389692 |
| Uniprot ID: | MAFA_HUMAN |
| Immunogen: | Synthesized peptide derived from the human MAFA at the amino acid range 204-254 |
| Immunogen Region: | 204-254 aa |
| Specificity: | This antibody detects endogenous levels of MAFA at Human/Mouse |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Phosphorylated at tyrosines. |
| Function | Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. |
| Protein Name | Transcription Factor MafaPancreatic Beta-Cell-Specific Transcriptional ActivatorRipe3b1 FactorV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Mafa antibodyAnti-Pancreatic Beta-Cell-Specific Transcriptional Activator antibodyAnti-Ripe3b1 Factor antibodyAnti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A antibodyAnti-MAFA antibody |
Information sourced from Uniprot.org
