Anti-MAEL antibody (STJA0008632)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MAEL
Gene ID:	84944
Uniprot ID:	MAEL_HUMAN
Specificity:	This antibody detects endogenous levels of MAEL at Human, Mouse
Immunogen:	Synthesized peptide derived from human MAEL

Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.
Protein Name	Protein Maelstrom Homolog
Database Links	Reactome: R-HSA-5601884
Cellular Localisation	Cytoplasm Nucleus Component Of The Meiotic Nuage Also Named P Granule A Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis Specifically Localizes To Pip-Bodies A Subset Of The Nuage Which Contains Secondary Pirnas
Alternative Antibody Names	Anti-Protein Maelstrom Homolog antibody Anti-MAEL antibody

Information sourced from Uniprot.org

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