| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. |
| Protein Name | Protein Maelstrom Homolog |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmNucleusComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisSpecifically Localizes To Pip-BodiesA Subset Of The Nuage Which Contains Secondary Pirnas |
| Alternative Antibody Names | Anti-Protein Maelstrom Homolog antibodyAnti-MAEL antibody |
Information sourced from Uniprot.org
