| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Leucine zipper putative tumor suppressor 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LZTS2 |
| Gene ID: | 84445 |
| Uniprot ID: | LZTS2_HUMAN |
| Specificity: | This antibody detects endogenous levels of LZTS2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human LZTS2 |
| Function | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
| Protein Name | Leucine Zipper Putative Tumor Suppressor 2Hlzts2Protein Lapser1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocalized To The Centrosome Throughout The Cell CycleLocalized To The Midbody In Cells Undergoing Cytokinesis |
| Alternative Antibody Names | Anti-Leucine Zipper Putative Tumor Suppressor 2 antibodyAnti-Hlzts2 antibodyAnti-Protein Lapser1 antibodyAnti-LZTS2 antibodyAnti-KIAA1813 antibodyAnti-LAPSER1 antibody |
Information sourced from Uniprot.org
