| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
LZTR1 |
| Gene ID: |
8216 |
| Uniprot ID: |
LZTR1_HUMAN |
| Immunogen Region: |
300-545 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). |
| Immunogen Sequence: |
GGAADNTLPNELHCYDVDFQ TWEVVQPSSDSEVGGAEVPE RACASEEVPTLTYEERVGFK KSRDVFGLDFGTTSAKQPTQ PASELPSGRLFHAAAVISDA MYIFGGTVDNNIRSGEMYRF QFSCYPKCTLHEDYGRLWES RQFCDVEFVLGEKEECVQGH VAIVTARSRWLRRKITQARE RLAQKLEQEAAPVPREAPGV AAGGARPPLLHVAIREAEAR PFEVLMQFLYTDKIKYPRK |
| Post Translational Modifications | Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. |
| Protein Name | Leucine-Zipper-Like Transcriptional Regulator 1Lztr-1 |
| Cellular Localisation | Endomembrane SystemRecycling EndosomeGolgi Apparatus |
| Alternative Antibody Names | Anti-Leucine-Zipper-Like Transcriptional Regulator 1 antibodyAnti-Lztr-1 antibodyAnti-LZTR1 antibodyAnti-TCFL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
