Anti-LYVE1 antibody [PT0449R] (STJA0039522)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0449R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1:1000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LYVE1 |
| Gene ID | 10894 |
| Uniprot ID | LYVE1_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | O-glycosylated. |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium. |
| Protein Name | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1Lyve-1Cell Surface Retention Sequence-Binding Protein 1Crsbp-1Extracellular Link Domain-Containing Protein 1Hyaluronic Acid Receptor |
| Database Links | Reactome: R-HSA-2160916 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal CompartmentsUndergoes Ligand-Dependent Internalization And Recycling At The Cell SurfaceLocalizes At Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 antibodyAnti-Lyve-1 antibodyAnti-Cell Surface Retention Sequence-Binding Protein 1 antibodyAnti-Crsbp-1 antibodyAnti-Extracellular Link Domain-Containing Protein 1 antibodyAnti-Hyaluronic Acid Receptor antibodyAnti-LYVE1 antibodyAnti-CRSBP1 antibodyAnti-HAR antibodyAnti-XLKD1 antibodyAnti-UNQ230 antibodyAnti-PRO263 antibody |
Information sourced from Uniprot.org